I have been taking Duloxetine for more than 3 years. I ran out once and had to wait a week for a prescription refill. During that week I had the usual withdrawal symptoms such as "brain zaps" or lack of concentration, but overall I felt awful. I think a great deal of my depression is related to pain. Before taking Duloxetine, I started taking 2 vicodin every morning and after doing so, I felt like showering and getting dressed was somehow easier. I was more productive on days I took vicodin in the morning. I noticed an even bigger improvement when I started taking the Duloxetine. Now I use Vicodin more of an as needed basis, which is better for my liver.
When I read the PubMed posted on Twitter by @fibroaction, I was happy to read “In addition, the efficacy of Duloxetine was found to be due to direct effects on pain symptoms rather than secondary to improvements in depression or anxiety." It's tough to just "walk off" chronic pain at such high levels.
It's good to see other patients will benefit from this pain relieving benefit and I am not imagining things. Sometimes pain is so frequent and intense, it really feels like I'm crazy. I may be a mental patient with depression, but I fell less like a nut today.